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Introduction to Bioinformatics

A complete, no-prerequisites introduction to bioinformatics. Start with the biology of DNA, RNA, and proteins, learn the file formats and public databases the field runs on, get comfortable in the command line, and finish able to fetch, inspect, analyze, and BLAST real biological sequences — no prior coding or biology required.

Introduction to Bioinformatics

Syllabus

Foundations3 lessons
  1. What is bioinformatics?10 min
  2. The molecules of life: DNA, RNA & protein9 min
  3. From gene to protein: transcription & translation12 min
Data & formats6 lessons
  1. The FASTA format: how sequences are stored10 min
  2. The FASTQ format: reads & quality scores10 min
  3. The bioinformatics file-format zoo10 min
    1. SAM & BAM: how alignments are stored8 min
    2. VCF: recording genetic variants8 min
    3. GFF, GTF & BED: annotations and intervals8 min
Hands-on terminal3 lessons
  1. Meet the command line: your workbench10 min
  2. Inspecting sequence files in the shell10 min
  3. Counting & filtering sequences10 min
Sequence analysis3 lessons
  1. Sequence composition: GC content10 min
  2. Reverse complement & the two strands11 min
  3. Translating DNA into protein11 min
Databases & search3 lessons
  1. Biological databases: NCBI, UniProt, Ensembl11 min
  2. Fetching a sequence by accession10 min
  3. Alignment & BLAST: what is this sequence?10 min
Wrap-up1 lessons
  1. A tiny workflow & where to go next12 min