BioUnfold Blog

Insights & Tutorials

Deep dives into bioinformatics, computational biology, and data science. Written by researchers, for researchers.

What Is Bioinformatics? A Beginner's Guide to the Field
BeginnerIntroduction

What Is Bioinformatics? A Beginner's Guide to the Field

An accessible introduction to bioinformatics, covering what it is, why it matters, and how biology and computer science converge to solve modern scientific challenges.

Jan 15, 20258 min
RNA-Seq Analysis: From Raw Reads to Differential Expression
RNA-SeqTranscriptomics

RNA-Seq Analysis: From Raw Reads to Differential Expression

A practical walkthrough of the RNA-Seq analysis pipeline, from quality control and alignment to differential gene expression using DESeq2.

Feb 10, 202512 min
The AlphaFold Revolution: How AI Solved Protein Structure Prediction
AlphaFoldAIProtein Structure

The AlphaFold Revolution: How AI Solved Protein Structure Prediction

How DeepMind's AlphaFold transformed structural biology, what it means for drug discovery, and how you can use it in your own research.

Mar 5, 202510 min
Molecular Docking with AutoDock Vina: A Practical Guide
Drug DiscoveryMolecular Docking

Molecular Docking with AutoDock Vina: A Practical Guide

Step-by-step guide to performing molecular docking simulations using AutoDock Vina, from ligand preparation to binding affinity analysis.

Apr 12, 202511 min
Single-Cell RNA-Seq: Understanding Cellular Heterogeneity
Single-CellscRNA-Seq

Single-Cell RNA-Seq: Understanding Cellular Heterogeneity

An introduction to single-cell RNA sequencing, how it differs from bulk RNA-Seq, and the computational tools used to analyze single-cell data.

May 20, 20259 min
Metagenomics: Decoding Microbial Communities Without Culturing
MetagenomicsMicrobiome

Metagenomics: Decoding Microbial Communities Without Culturing

How metagenomic sequencing reveals the hidden world of microbial ecosystems and the bioinformatics tools used to analyze them.

Jun 18, 202510 min
Machine Learning in Drug Discovery: From Molecules to Medicine
Machine LearningDrug Discovery

Machine Learning in Drug Discovery: From Molecules to Medicine

How machine learning is accelerating drug discovery, from molecular property prediction to generative chemistry and clinical trial optimization.

Jul 22, 202511 min
CRISPR and Bioinformatics: Designing Guide RNAs and Analyzing Edits
CRISPRGenome Editing

CRISPR and Bioinformatics: Designing Guide RNAs and Analyzing Edits

The computational side of CRISPR genome editing — from guide RNA design to off-target prediction and editing outcome analysis.

Aug 15, 20259 min