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Genomics 101

Understand the principles of genomics, including genome assembly, annotation, variant calling, and how next-generation sequencing technologies are transforming biological discovery.

Genomics 101

Syllabus

Genome foundations3 lessons
  1. What Is a Genome?10 min
  2. Genes, Chromosomes, and Non-coding DNA11 min
  3. Reference Genomes and Genome Builds11 min
Sequencing DNA3 lessons
  1. From Sanger to Next-Generation Sequencing10 min
  2. How NGS Works: Reads and the FASTQ Format10 min
  3. Reads, Depth, and Coverage10 min
From reads to variants4 lessons
  1. Genome Assembly: De Novo vs Reference-Guided11 min
  2. Mapping Reads to a Reference Genome11 min
  3. Genetic Variation: SNPs and Indels11 min
  4. Variant Calling and the VCF Format11 min
Interpreting & exploring genomes3 lessons
  1. Genome Annotation: Genes and Variant Effects10 min
  2. Exploring Genomes with UCSC and IGV11 min
  3. Putting It All Together and Where to Go Next11 min